3-(4-chlorophenyl)-2-methylpropanoic acid
3-(4-Chloro-phenyl)-2-methyl-propionic acid
CAS: 1012-17-5
Molecular Formula: C10H11ClO2
3-(4-chlorophenyl)-2-methylpropanoic acid - Names and Identifiers
3-(4-chlorophenyl)-2-methylpropanoic acid - Physico-chemical Properties
| Molecular Formula | C10H11ClO2 |
| Molar Mass | 198.65 |
| Storage Condition | Room Temprature |
| Sensitive | Irritant |
| MDL | MFCD08445717 |
3-(4-chlorophenyl)-2-methylpropanoic acid - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Hazard Class | IRRITANT |
3-(4-chlorophenyl)-2-methylpropanoic acid - Introduction
3-(4-Chloro-phenyl)-2-methyl-propionic acid is an organic compound with the chemical formula C10H11ClO2. The following is a detailed description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: Colorless or slightly yellow crystalline solid
-melting point: 57-61 ℃
-Boiling point: 338.6 ℃
-Density: 1.13g/cm³
-Solubility: Soluble in ether, alcohol and ester solvents, slightly soluble in water.
Use:
- 3-(4-Chloro-phenyl)-2-methyl-propionic acid can be used as intermediates and pharmaceutical raw materials in organic synthesis.
-It can be used to synthesize anti-inflammatory, antibacterial and antitumor drugs, etc.
Preparation Method:
3-(4-Chloro-phenyl)-2-methyl-propionic acid can be synthesized by the following steps:
1. Propionic acid reacts with sulfuric acid chloride to obtain vinyl chloride.
2. A vinyl chloride and benzaldehyde are subjected to a thermal condensation reaction to obtain phenylacetone.
3. Phenylacetone is reacted with cuprous chloride (CuCl) to obtain 3-(4-chlorophenyl)-2-methylacetone.
4. Acidification of 3-(4-chlorophenyl)-2-methylacetone by heating to give 3-(4-Chloro-phenyl)-2-methyl-propionic acid.
Safety Information:
- 3-(4-Chloro-phenyl)-2-methyl-propionic acid is an organic compound that should be carefully protected from contact with the skin, eyes and respiratory system.
-When in use, should be equipped with appropriate protective equipment, such as chemical protective clothing, protective glasses and masks.
-Good ventilation should be maintained during operation.
-In the event of accidental contact or ingestion, seek medical attention immediately and bring a safety data sheet or packaging for the substance.
Nature:
-Appearance: Colorless or slightly yellow crystalline solid
-melting point: 57-61 ℃
-Boiling point: 338.6 ℃
-Density: 1.13g/cm³
-Solubility: Soluble in ether, alcohol and ester solvents, slightly soluble in water.
Use:
- 3-(4-Chloro-phenyl)-2-methyl-propionic acid can be used as intermediates and pharmaceutical raw materials in organic synthesis.
-It can be used to synthesize anti-inflammatory, antibacterial and antitumor drugs, etc.
Preparation Method:
3-(4-Chloro-phenyl)-2-methyl-propionic acid can be synthesized by the following steps:
1. Propionic acid reacts with sulfuric acid chloride to obtain vinyl chloride.
2. A vinyl chloride and benzaldehyde are subjected to a thermal condensation reaction to obtain phenylacetone.
3. Phenylacetone is reacted with cuprous chloride (CuCl) to obtain 3-(4-chlorophenyl)-2-methylacetone.
4. Acidification of 3-(4-chlorophenyl)-2-methylacetone by heating to give 3-(4-Chloro-phenyl)-2-methyl-propionic acid.
Safety Information:
- 3-(4-Chloro-phenyl)-2-methyl-propionic acid is an organic compound that should be carefully protected from contact with the skin, eyes and respiratory system.
-When in use, should be equipped with appropriate protective equipment, such as chemical protective clothing, protective glasses and masks.
-Good ventilation should be maintained during operation.
-In the event of accidental contact or ingestion, seek medical attention immediately and bring a safety data sheet or packaging for the substance.
Last Update：2024-04-09 02:00:56
